Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate

Name: Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate
Brand: America Suns Life
Price: 700 USD
Availability: InStock

CAS Number: 1428243-26-8

Category: Upadacitinib Intermediates

Synonyms: (3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester, Cbz-(3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine

Request a Quote

✓ GMP-compliant ✓ Commercial supply&ample stock ✓ Various Packaging Available ✓ Factory documentation support

Product Specifications

CAS Number	1428243-26-8
Molecular Formula	C16H20BrNO3
Molecular Weight	354.24
Purity	≥99.0%
Appearance	White to off-white solid
Storage Conditions	2-8°C
Package	From 100g/bottle to 25kg/drum

Product Overview

CAS 1428243-26-8 Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate (also named (3R,4S)-3-(2-bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester).

Applications

Stereospecific Chiral Scaffold: Features a trans-disubstituted pyrrolidine ring with defined (3R, 4S) stereochemistry and an N-protecting carbamate (Cbz/benzyl ester) group.

Reactive Electrophilic Handle: Contains an alpha-halo ketone (alpha-bromoacetyl) group at the C3 position, making it a versatile electrophilic synthon for nucleophilic substitutions and heterocycle ring constructions (e.g., aminothiazole or imidazo-ring formations).

Pharmaceutical Intermediate: Widely used as a key advanced intermediate in the synthesis of kinase inhibitors and immunosuppressive agents, most notably in the preparation of Upadacitinib (a selective JAK1 inhibitor).