Ethyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

Name: Ethyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate
Brand: America Suns Life
Price: 800 USD
Availability: InStock

CAS Number: 1869118-24-0

Category: Upadacitinib Intermediates

Synonyms: Carbamic acid, N-[5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazin-2-yl]-, ethyl ester; ethyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate

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Product Specifications

CAS Number	1869118-24-0
Molecular Formula	C16H16N4O4S
Molecular Weight	360.39
Purity	≥99.0%
Appearance	White to off-white solid
Storage Conditions	2-8°C
Package	From 100g/bottle to 25kg/drum

Product Overview

CAS 1869118-24-0 Ethyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate (also named ethyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate).

Applications

Bicyclic Core: Contains a fused pyrrolo[2,3-b]pyrazine bicyclic heterocycle, structurally related to pyrrolo[2,3-b]pyridines (7-azaindoles).

Protecting Group Strategy: Features dual orthogonal protection with an ethyl carbamate group protecting the C2 amino functionality and a Ts (tosyl) protecting group on the pyrrole nitrogen (N5) to maintain stability and directed reactivity during synthesis.

Medicinal Chemistry Intermediate: Closely related to tert-butyl analogues (such as CAS 1201187-44-1), serving as a crucial heterocyclic building block for synthesizing kinase inhibitors and other nitrogen-rich pharmaceutical leads.