tert-Butyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

CAS Number: 1201187-44-1
Category: Upadacitinib Intermediates
Synonyms: tert-Butyl (5-((4-methylphenyl)sulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate, 2-(Boc-amino)-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
✓ GMP-compliant ✓ Commercial supply&ample stock ✓ Various Packaging Available ✓ Factory documentation support

Product Specifications

CAS Number1201187-44-1
Molecular FormulaC18H20N4O4S
Molecular Weight388.44
Purity≥99.0%
AppearanceWhite to off-white solid
Storage Conditions2-8°C
PackageFrom 100g/bottle to 25kg/drum

Product Overview

CAS 1201187-44-1 tert-Butyl (5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate (also named tert-butyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate).

Applications

Heterocyclic Core: Features a fused pyrrolo[2,3-b]pyrazine bicyclic framework, a bioisostere to pyrrolo[2,3-b]pyridine (7-azaindole) and imidazopyrazine rings.

Protecting Group Strategy: Dual-protected building block possessing an N-Boc protecting group at the 2-amino position and a Ts (tosyl) protecting group on the pyrrole nitrogen (N5) to ensure orthogonal reactivity during cross-couplings and functional group manipulations.

Medicinal Chemistry Use: Widely utilized as an advanced intermediate in kinase inhibitor development and pharmaceutical synthesis targeting kinase signaling pathways.

Quality Assurance

Can be tested according to the customer’s method of analysis.

Certificate of Analysis (COA) and Material Safety Data Sheets (MSDS) provided upon request.