(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol

(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol

CAS Number: 127852-28-2
Category: Aprepitant Intermediates
Synonyms: (1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol [(cite: 1.1.4)]
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Product Specifications

CAS Number127852-28-2
Molecular FormulaC10H8F6O
Molecular Weight258.16
Purity≥99.0%
AppearanceWhite to off-white solid
Storage ConditionsRoom Temperature
PackageFrom 100g/bottle to 25kg/drum

Product Overview

1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-one (CAS: 127852-28-2) is an organofluorine ketone and key aromatic building block widely used in organic synthesis and pharmaceutical manufacturing.

Applications

Serves as the primary precursor for asymmetric reduction to form (S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol, an essential chiral intermediate used in the synthesis of neurokinin-1 (NK1) receptor antagonists such as Aprepitant, Fosaprepitant, and Rolapitant.

Quality Assurance

Can be tested according to the customer’s method of analysis.

Certificate of Analysis (COA) and Material Safety Data Sheets (MSDS) provided upon request.

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